https://ogma.newcastle.edu.au/vital/access/ /manager/Index en-au 5 No reliable association between runs of homozygosity and schizophrenia in a well-powered replication study https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:27630 Froh and schizophrenia (β = 4.86,CI(β) = [0.90,8.83],Z = 2.40,p = 0.02). Since Keller et al. (2012), several studies reported inconsistent association of ROH burden with complex traits, particularly in case-control data. These conflicting results might suggest that the effects of autozygosity are confounded by various factors, such as socioeconomic status, education, urbanicity, and religiosity, which may be associated with both real inbreeding and the outcome measures of interest.]]> Wed 11 Apr 2018 14:15:34 AEST ]]> A polygenic resilience score moderates the genetic risk for schizophrenia: Replication in 18,090 cases and 28,114 controls from the Psychiatric Genomics Consortium https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54811 Thu 14 Mar 2024 14:24:56 AEDT ]]> Biological insights from 108 schizophrenia-associated genetic loci https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21465 DRD2 and several genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses. Independent of genes expressed in brain, associations were enriched among genes expressed in tissues that have important roles in immunity, providing support for the speculated link between the immune system and schizophrenia.]]> Sat 24 Mar 2018 07:52:31 AEDT ]]> Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:29335 Sat 24 Mar 2018 07:34:19 AEDT ]]> A polygenic resilience score moderates the genetic risk for schizophrenia https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38229 Mon 16 Aug 2021 17:39:39 AEST ]]>